Myopathy Statins And Vitamin D Deficiency
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The relationship of vitamin D deficiency to statin myopathyAbstract
Objective
Our goal was to examine the interaction between vitamin D and statins and the possible role of vitamin D deficiency in statin myopathy.
Background
The vitamin D receptor is present in skeletal muscle and vitamin D deficiency can cause myopathy. Statins (3-hydroxy-3-methyl-glutaryl-CoA reductase inhibitors) are generally well tolerated, but have been associated with a spectrum of skeletal muscle complaints, ranging from myalgia and asymptomatic mild elevations of creatine kinase (CK) to rhabdomyolysis. There has been recent interest in the possible interaction between statin myopathy and vitamin D deficiency. We performed a systematic medical literature review to examine this possible relationship.
Methods
We identified English language articles relating statins, vitamin D and statin myopathy via a PubMed search through July 2010. Articles pertinent to the topic were reviewed in detail.
Results/conclusions
Our review suggests that some but not all statins increase 25(OH) D levels. Two cross sectional studies have associated vitamin D deficiency with statin-associated myalgias, and suggested that that increasing vitamin D levels can reverse the myalgia. Nevertheless, given the quality and paucity of studies examining this possibility, additional studies are needed to examine the potential role of vitamin D deficiency in statin myopathy. It is presently premature to recommend vitamin D supplementation as treatment for statin associated muscle complaints in the absence of low vitamin D levels although such supplementation could be tried in patients with deficient or reduced vitamin D levels.
Keywords
Statins
Myopathy
Muscle
Skeletal muscle
HMG-CoA reductase inhibitors
Lipids
Vitamin D
Vitamin D deficiency
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.
Myopathy Statins And Vitamin D Deficiency
Source: https://www.sciencedirect.com/science/article/pii/S0021915010009780
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